Neurophysiologic aspects of deep brain stimulation
Identifieur interne : 003574 ( Main/Exploration ); précédent : 003573; suivant : 003575Neurophysiologic aspects of deep brain stimulation
Auteurs : P. Ashby [Canada] ; J. C. Rothwell [Royaume-Uni]Source :
- Neurology [ 0028-3878 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Parkinson Disease, Tremor, Ventral Thalamic Nuclei.
- therapy : Parkinson Disease, Tremor.
- Electric Stimulation Therapy, Humans.
Abstract
Article abstract-Implanting electrodes for deep brain stimulation (DBS) allows performance of a number of different neurophysiologic studies. Before definitive internalization of the device, recording and stimulation through the electrodes is possible. Stimulation of the globus pallidum produced a mixture of excitation and inhibition of ongoing muscle activity. The excitatory response is probably produced by activation of the large-diameter fibers of the corticospinal tract. Stimulation of the thalamus is mainly associated with EMG inhibition. These findings indicate that the effect of stimulation may vary in different targets and that the mechanism of action of DBS is heterogeneous. A different type of study concerns those undertaken after chronic DBS of the subthalamic nucleus (STN) and globus pallidum internum (GPi) in parkinsonian patients. Cortical mechanisms subserving movement preparation and execution have been assessed. The main findings were that stimulation had a more prominent effect on execution than on preparation and that this was greater in patients treated with STN DBS than GPi DBS.
Affiliations:
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Rothwell</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Human Movement and Balance MCR Unit, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">01-0106164</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 01-0106164 INIST</idno><idno type="RBID">Pascal:01-0106164</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C49</idno><idno type="wicri:Area/PascalFrancis/Curation">000074</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B76</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B76</idno><idno type="wicri:doubleKey">0028-3878:2000:Ashby P:neurophysiologic:aspects:of</idno><idno type="wicri:Area/Main/Merge">003B10</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:11188969</idno><idno type="wicri:Area/PubMed/Corpus">001672</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001672</idno><idno type="wicri:Area/PubMed/Curation">001672</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001672</idno><idno type="wicri:Area/PubMed/Checkpoint">001672</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001672</idno><idno type="wicri:Area/Ncbi/Merge">000143</idno><idno type="wicri:Area/Ncbi/Curation">000143</idno><idno type="wicri:Area/Ncbi/Checkpoint">000143</idno><idno type="wicri:doubleKey">0028-3878:2000:Ashby P:neurophysiologic:aspects:of</idno><idno type="wicri:Area/Main/Merge">003870</idno><idno type="wicri:Area/Main/Curation">003574</idno><idno type="wicri:Area/Main/Exploration">003574</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Neurophysiologic aspects of deep brain stimulation</title><author><name sortKey="Ashby, P" sort="Ashby, P" uniqKey="Ashby P" first="P." last="Ashby">P. Ashby</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Neurophysiology Service, The Toronto Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Human Movement and Balance MCR Unit, Queen Square</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (vertebrata)</term><term>Electric Stimulation Therapy</term><term>Electrophysiology</term><term>Human</term><term>Humans</term><term>Instrumental stimulation</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Treatment</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term><term>Ventral Thalamic Nuclei (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Stimulation instrumentale</term><term>Encéphale</term><term>Electrophysiologie</term><term>Traitement</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Article abstract-Implanting electrodes for deep brain stimulation (DBS) allows performance of a number of different neurophysiologic studies. Before definitive internalization of the device, recording and stimulation through the electrodes is possible. Stimulation of the globus pallidum produced a mixture of excitation and inhibition of ongoing muscle activity. The excitatory response is probably produced by activation of the large-diameter fibers of the corticospinal tract. Stimulation of the thalamus is mainly associated with EMG inhibition. These findings indicate that the effect of stimulation may vary in different targets and that the mechanism of action of DBS is heterogeneous. A different type of study concerns those undertaken after chronic DBS of the subthalamic nucleus (STN) and globus pallidum internum (GPi) in parkinsonian patients. Cortical mechanisms subserving movement preparation and execution have been assessed. The main findings were that stimulation had a more prominent effect on execution than on preparation and that this was greater in patients treated with STN DBS than GPi DBS.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Ashby, P" sort="Ashby, P" uniqKey="Ashby P" first="P." last="Ashby">P. Ashby</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rothwell, J C" sort="Rothwell, J C" uniqKey="Rothwell J" first="J. C." last="Rothwell">J. C. Rothwell</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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